منابع مشابه
Ferns and Heikal, Atherogenesis and hypoxia Hypoxia in Atherogenesis
The anoxemia theory proposes that an imbalance between the demand for, and supply of, oxygen in the arterial wall is a key factor in the development of atherosclerosis. There is now substantial evidence that there are regions within the atherosclerotic plaque in which profound hypoxia exists; this may fundamentally change the function, metabolism and responses of many of the cell types found wi...
متن کاملThe microcirculation in atherogenesis.
The term ‘atherosclerosis’ is generally employed for a disease process characterized by the formation of atheromas (fibrofatty intimal plaques) resulting in progressive hardening of the arterial wall, loss of vascular elasticity, and luminal compromise. Different segments of the vascular tree vary in their susceptibility to develop atherosclerotic lesions: atheromas have been described characte...
متن کاملHypoxia in Atherogenesis.
The anoxemia theory proposes that an imbalance between the demand for and supply of oxygen in the arterial wall is a key factor in the development of atherosclerosis. There is now substantial evidence that there are regions within the atherosclerotic plaque in which profound hypoxia exists; this may fundamentally change the function, metabolism, and responses of many of the cell types found wit...
متن کاملAngiogenesis in atherogenesis.
Atherogenesis is the pathobiological process, which underlies atherosclerotic cardiovascular disease and evolves in the 3 stages of initiation, progression, and complication to clinical significance. Of note, this process is associated with neovascularization, and it was not until recently that the implications of angiogenesis in atherogenesis were delineated. This article gives an updated over...
متن کاملAtherogenesis in Diabetes
A bout 45 years ago George Lyman Duff, together / \ with Gardner McMillan, presented a paper J. \ . called "The Effect of Alloxan Diabetes on Experimental Cholesterol Atherosclerosis in the Rabbit" at the Second Annual Meeting of the American Society for the Study of Arteriosclerosis, and two papers describing that work were subsequently published in the Journal of Experimental Medicine in 1949...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2018
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2018.02.014